Original Research

Assessment of QTc Interval Prolongation and its Relationship withGlycemic Control in Diabetic Populations across Demographic andClinical Spectrums

Shahnaz Noor1
Qauid-e-Azam Medical College, Bahawalpur
Rabia Saeed2
CMH Institute of Medical Sciences Bahawalpur
Sara Khan2
CMH Institute of Medical Sciences Bahawalpur
Muhammad Haroon Bilal3
Dera Ghazi Khan Medical College, D.G. Khan
Naveed Nayyer1
Qauid-e-Azam Medical College, Bahawalpur
Jalil Iqba4
Shahida Islam Medical College Lodhran

✉ Correspondence: Shahnaz Noor Email: drshan.noor@gmail.com

DOI https://doi.org/10.70302/jpsim.v5i1.2412
Volume: 5, Issue 1 (Women Issue) Pages: 413–417 Published: 28 Feb 2024
Received: 09 Oct 2023 Accepted: 21 Dec 2023 Published Online: 28 Feb 2024

Abstract

Objective

To assess the QTc Interval Prolongation and its Relationship with Glycemic Control in Diabetic Populations across Demographic and Clinical Spectrums.

Methods

This cross-sectional study was carried out with outpatients visiting the Department of Medicine at Quaid-e-Azam Medical College in Bahawalpur, from November 2022 to May 2023. It involved a total of 255 diabetic patients, encompassing both genders, aged between 40 and 70 years. The focus was on evaluating the prolonged QTc interval.

Results

The mean age of the patients is 54.23 ± 9.49 years, the HbA1c level is 7.32 ± 0.449, and the mean QTc interval is 439.88 ± 14.795 milliseconds, respectively. Among the 255 diabetic patients studied, prolonged QTc was noted in 98 (38%) of them. The mean HbA1c level for patients with prolonged QTc is 7.40 ± 0.374 contrasting with a slightly lower mean of 7.27 ± 0.485 in patients without prolonged QTc. The statistical significance of this difference is underscored by a P value of 0.024.

Conclusion

In conclusion, our study of 255 diabetic patients, showed a high prevalence of prolonged QTc intervals, observed in 38% of the patients. The study highlighted a significant correlation between prolonged QTc intervals and HbA1c levels, particularly pronounced in specific demographic and clinical subgroups. Elevated HbA1c levels were more frequently associated with QTc prolongation, especially in younger patients (40-55 years) and those with dyslipidemia. However, the study found no significant difference in QTc prolongation between genders.

Keywords
: QTc dispersion Glucose variability type 2 diabetes ECG QTinterval

How to Cite This Article

Noor S, Saeed R, Khan S, Bilal MH, Nayyer N, Iqba J. Assessment of QTc Interval Prolongation and its Relationship withGlycemic Control in Diabetic Populations across Demographic andClinical Spectrums. J Pak Soc Intern Med. 2024;5(1):413–417. doi:10.70302/jpsim.v5i1.2412

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2024 Journal of Pakistan Society of Internal Medicine.
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