Study Demonstrating Simple, Cheap and Effective Regimen for Helicobacter Pylori Eradication at a Teaching Hospital of Sindh

Without or partial treatment of Helicobacter pylori infection is associated with chronic gastritis and gastric
malignancies in our setup. The aim of this study is to plan a simple, cheap and effective regimen for eradication of H. pylori
infection at a teaching hospital of Sindh.

We performed a retrospective study comprising of 185 stool antigen test positive patients at Medicine Depart
ment of Suleiman Roshan Medical College Hospital Tando-Adam Sanghar Sindh from 01 January to 30th October 2023.
These treatment naïve patients were prescribed seven days triple therapy regimen containing vonoprazan 20 mg bid, amoxicillin
1.0 gm bid and tinidazole 500 mg bid daily. The eradication of H. pylori was confirmed via stool antigen test performed four
weeks after completion of therapy.

Intention-to-treat and per-protocol analyses discovered that our regimen showed better eradication rate 88.2%
(95% CI, 80-95%) and 91.89% (95% CI, 84-97%) respectively. Major adverse effects were noted in 15 (8.82%) of patients
and only 05 (2.94%) still remained positive after completion of therapy.

Seven days vonoprazan-based triple therapy is a potential first line H. pylori eradication regimen in
developing countries as it is simple (low pills burden), cheap, shorter duration of treatment and fewer major adverse
effects.