Original Research

Curcumin's Neuroprotective Effects on the Neurons of the Rat Cerebrum's Motor Cortex against Tartrazine's Neurotoxic Effects

Maleeha Zafar1
Heavy Industries Taxila Education City -Institute of Medical Sciences Taxila
Sobia Javaid2
Rawalpindi Medical University
Salma Ambreen Shahab1
Heavy Industries Taxila Education City -Institute of Medical Sciences Taxila
Ayesha Fatima1
Heavy Industries Taxila Education City -Institute of Medical Sciences Taxila
Kaukab Anjum3
Department of Anatomy Wah Medical College Wah Cantt
Saqib Nasir1
Heavy Industries Taxila Education City -Institute of Medical Sciences Taxila
Ayesha Shahid1
Heavy Industries Taxila Education City -Institute of Medical Sciences Taxila
Iram Zakria1
Heavy Industries Taxila Education City -Institute of Medical Sciences Taxila
Hina Rafique1
Heavy Industries Taxila Education City -Institute of Medical Sciences Taxila

✉ Correspondence: Maleeha Zafar Email: maleeha.wcpk@gmail.com

DOI https://doi.org/10.70302/jpsim.v5i3.2456
Volume: 5, Issue 3 Pages: 640–643 Published: 30 Aug 2024
Received: 14 Feb 2024 Accepted: 07 Aug 2024 Published Online: 30 Aug 2024

Abstract

Objective

To assess the potential mitigating impact of curcumin on any potential neurotoxic effects induced by tartrazine.

Methods

This random control trial involved 45 adult male rats with weights ranging from 250-300g, randomly divided into III groups, each consisting of 15 rats (n=15). Group I was given a standard diet. Group II received tartrazine by dissolving in tap water, at a dose of 7.5 mg/kg of body weight. Group III was administered both 200 mg/kg of curcumin and tartrazine orally, daily for period of twenty-eight days. At the conclusion of the study, the animals were euthanized, and their brains were dissected. Following embedding, coronal sections of 5μm thickness were obtained and stained with haematoxylin eosin to visualize the degenerative changes in the neurons of rat motor cortex. Results were analysed using SPSS version 21.

Results

Histologically significant ameliorative effects of curcumin were observed in terms of improvement in pyramidal cell degeneration and granule cell necrosis in motor cortex of rat cerebrum. Encouraging the limitation of artificial dyes, particularly in children's diets, is advisable. Opting for a diet devoid of artificial food coloring or substituting tartrazine, with Curcumin, a natural alternative, is recommended.

Conclusion

Curcumin is a budding solution for alleviating tartrazine-induced neurotoxicity, thanks to its antioxidative, anti-neuroinflammatory, and anti-apoptotic attributes.

Keywords
Curcumin Food dyes Pyramidal neurons Neuroprotection Tartrazine

How to Cite This Article

Zafar M, Javaid S, Shahab SA, Fatima A, Anjum K, Nasir S, et al.. Curcumin's Neuroprotective Effects on the Neurons of the Rat Cerebrum's Motor Cortex against Tartrazine's Neurotoxic Effects. J Pak Soc Intern Med. 2024;5(3):640–643. doi:10.70302/jpsim.v5i3.2456

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2024 Journal of Pakistan Society of Internal Medicine.
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