Original Research

Polyethylene Glycol in the Treatment of Hepatic Encephalopathy in patients with Liver Cirrhosis

Kamran Amir Khan1
Northwest General Hospital and Research Center, Peshawar
Sameed Ullah Qureshi1
Northwest General Hospital and Research Center, Peshawar
Zuhra Naheed Khan2
Pakistan kidney and liver institute, Lahore

✉ Correspondence: Kamran Amir Khan Email: kkhan@nwgh.pk

DOI https://doi.org/10.70302/jpsim.v6i4.2569
Volume: 6, Issue 4 Pages: 373–375 Published: 21 Nov 2025
Received: 11 Apr 2024 Revised: 14 Jun 2025 Accepted: 10 Oct 2025 Published Online: 21 Nov 2025

Abstract

Objective

This study aims to determine the effectiveness and safety of polyethylene glycol (PEG) in patients with hepatic encephalopathy.

Methods

This cross-sectional study was conducted at Northwest General Hospital and Research Centre, Peshawar, Pakistan. All patients participated in this study were diagnosed with hepatic encephalopathy from January 2019 to August 2021. All patients were given 3 sachets of polyethylene glycol daily. Recovery days, length of hospital stay, and recurrent episodes were assessed.

Results

A total of 75 patients with different hepatic diseases admitted to the hospital due to hepatic encephalopathy were given 3 sachets of polyethylene glycol daily. On average, 2.81 days for recovery and 5 days of hospital stay were required. The mean number of recurrent hepatic encephalopathy episodes was 0.52.

Conclusion

Polyethylene glycol is considered effective and safe in patients with hepatic encephalopathy, with short recovery days, hospital stay, and few recurrent episodes.

Keywords
Hepatic encephalopathy polyethylene glycol liver cirrhosis.

How to Cite This Article

Khan KA, Qureshi SU, Khan ZN. Polyethylene Glycol in the Treatment of Hepatic Encephalopathy in patients with Liver Cirrhosis. J Pak Soc Intern Med. 2025;6(4):373–375. doi:10.70302/jpsim.v6i4.2569

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2025 Journal of Pakistan Society of Internal Medicine.
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