Young Female who Presented with Hemoptysis
Abstract
Goodpasture syndrome is a rare autoimmune disorder characterized by pulmonary hemorrhage and glomerulonephritis, due to formation of auto-antibodies against type 4 collagen protein.In it’s typically form pulmonary haemorrhage presents before, and more often the initial presentation, before the onset of end-stage renal disease (ESRD) secondary to Chronic GN. The development of pulmonary hemorrhage after progression to ESRD is an uncommon and unique phenomenon as represented in this case study. This is a case of 20-year-old unmarried female from Narowal, a known case of ESRD secondary to chronic glomerulonephritis, who presented with a three-day history of progressive dyspnea (NYHA Class III) and left-sided chest pain, along with light headedness and palpitations. Systemic inquiry revealed malaise, low-grade fever, and anorexia. There was no significant family history; she belonged to a low income house hold. Lastly there she had no known allergies, with no significant travel history and history of completed childhood vaccination. This case represents the peculiarity with the atypical presentation of pulmonary Hemorrhage after the progression to ESRD in Goodpasture syndrome, it is a rare and underreported occurrence. This finding shows the importance of prompt recognition and multidisciplinary management cases complex as these. This report contributes to the growing understanding of Goodpasture syndrome's varied clinical course and outcomes in ESRD patients.
How to Cite This Article
Yousaf S, Irshad MI. Young Female who Presented with Hemoptysis. J Pak Soc Intern Med. 2025;6(4):376–379. doi:10.70302/jpsim.v6i4.2570
Conflict of Interest
All authors declare no competing interests.
Funding
No specific funding was received for this research.
Funder information follows the Crossref Funder Registry standard.
References
- Scott R Henderson, Alan D Salama, Diagnostic and management challenges in Goodpasture’s (anti-glomerular basement membrane) disease. Nephrol Dialysis Transplant. 2018;33(2):196-202.
- Li WL, Wang X, Zhang SY, Xu ZG, Zhang YW, Wei X, et al. Goodpasture syndrome and hemorrhage after renal biopsy: A case report. World J Clin Cases. 2020;8(2):404-9.
- Shah DS. Pulmonary Hemorrhage and Dialysis: A Case of Goodpasture’s in a Young Adult. BMJ Case Reports. 2017;.https://doi.org/10.1016/j.transci.2010.01.004. doi:10.1016/j.transci.2010.01.004
- Boardman EA, Sohail S, Yadavilli R. Goodpasture's disease with late presentation of renal abnormality and anti-GBM autoantibody. BMJ Case Rep. 2017; doi: 10.1136/bcr-2016-218705. doi:10.1136/bcr-2016-218705
- Levin M, Rigden SP, Pincott JR, Lockwood CM, Barratt TM, Dillon MJ. Goodpasture's syndrome: treatment with plasmapheresis, immunosuppression, and anticoagulation. Arch Dis Child. 1983;58(9):697-702.
- Zignego AL, Gragnani L, Giannini C, Laffi G. The hepatitis C virus infection as a systemic disease. Intern Emerge Med. 2012;7(Suppl 3):201-8.
- Kim YO, Choi JY, Park JI, Yoon SA, Yang CW, Kim KH. A case of Goodpasture's syndrome with massive pulmonary hemorrhage. J Korean Med Sci. 2000;15(1):99-102.
- Jiao LP, Fan JF, Sun Q, Shen Y. Plasma exchange in Goodpasture syndrome associated with Turner’s syndrome: A case report. Afr Health Sci. 2012;12(4):572-5.
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