Original Research

Vitamin D Deficiency in Premenopausal Women and Impact of its Replacement Therapy on Uterine Fibroid Growth

Sajida Razzaq
Sir Ganga Ram Hospital, Lahore
Uzma Aziz
Sir Ganga Ram Hospital, Lahore
Sehrish Habib
Sir Ganga Ram Hospital, Lahore

✉ Correspondence: Sajida Razzaq Email: noorkhanniazi@hotmail.com

DOI https://doi.org/10.70302/jpsim.v7i3.2639
Volume: 7, Issue 3 Pages: 202–206 Published: 21 Aug 2026
Received: 25 Nov 2025 Revised: 15 Jun 2026 Accepted: 12 Aug 2026 Published Online: 21 Aug 2026

Abstract

Objective

To ascertain the average change in fibroid size in women who are vitamin D deficient following vitamin D supplementation.

Methods

This Quasi experimental trial was conducted at Department of Obstetrics and Gynecology, Sir Ganga ram hospital, Lahore from 18th July 2022 to 17th January 2023. A total of 115 premenopausal women between 40 and 45; vitamin D deficiency proven by laboratory analysis; women with uterine fibroids of size less than 5 centimeter on ultrasound were included. Patients who have had vitamin D supplementation in the last 1 year; women taking regular calcium and vitamin D daily supplementation; pregnant or lactating women; women with autoimmune disorders, endocrinopathies, malignancy or on-going infectious disease; history of prior myomectomy or intervention for fibroids were excluded. Vitamin D 2 lac unit injection supplementation, once weekly for 12 weeks per orally was given. At the start of the study, all women had an ultrasound that measures the size and volume of the uterine fibroid and vitamin D level was checked.

Results

In my study, mean fibroid size at baseline and post-treatment was 34.23 ± 9.66 mm and 27.18 ± 9.39 mm respectively (p-value <0.0001). In women who were vitamin D deficient, the mean change in fibroid size following vitamin D supplementation was 6.79 ± 1.98 mm.

Conclusion

This study found that vitamin D supplementation decreases fibroid size in women who are vitamin deficient.

Keywords
uterine fibroid vitamin D deficiency vitamin D Supplementation.

How to Cite This Article

Razzaq S, Aziz U, Habib S. Vitamin D Deficiency in Premenopausal Women and Impact of its Replacement Therapy on Uterine Fibroid Growth. J Pak Soc Intern Med. 2026;7(3):202–206. doi:10.70302/jpsim.v7i3.2639

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Conflict of Interest

The authors declare no conflict of interest.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

This research received no specific grant from any funding agency.

Funder information follows the Crossref Funder Registry standard.

Ethics Statement

not_applicable

Conducted in accordance with the Declaration of Helsinki.

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CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2026 Journal of Pakistan Society of Internal Medicine.
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