Primary Hyperaldosteronism in a 38 Year Old Woman from Pakistan: A Case Report on Conn's Syndrome
Abstract
Conn’s syndrome refers to excess production of aldosterone by adrenal glands leading to an increase in blood pressure of the patient. There are often various other associated signs and symptoms due to which a patient may present often due to fluid overload and/or electrolyte abnormality. A 38 year old married female presented to the clinical with a raised blood pressure of 150-170 mmHg systolic and 100-120 mmHg diastolic. She also had a history of raised blood pressure during pregnancy with the first pregnancy being aborted and the second and third having markedly raised blood pressures. There was no associated history of palpitations, headache or anxiety. Her workup was done with a high aldosterone concentration and a low serum renin being detected. Her electrolytes were found to be normal and on ultrasound her kidneys were also normal. The patient was started verapamil to lower her blood pressure and a diagnoses of primary hyperaldosteronism was reached as the Plasma aldosterone to Renin ratio was raised with absence of any other cause.
How to Cite This Article
Khan SA, Suchal ZA, Saleem M, Badini K, Shaikh A. Primary Hyperaldosteronism in a 38 Year Old Woman from Pakistan: A Case Report on Conn's Syndrome. J Pak Soc Intern Med. 2022;3(1):63–65. doi:10.70302/jpsim.v3i1.2213
Conflict of Interest
All authors declare no competing interests.
Funding
No specific funding was received for this research.
Funder information follows the Crossref Funder Registry standard.
References
- Lee FT, Elaraj D. Evaluation and Management of Primary Hyperaldosteronism. Surg Clinics North Am. 2019;99(4):731-45.
- Kucharz EJ. Michał Lityński--a forgotten author of the first description on primary hyperaldosteronism. Pol Arch Med Wewn. 2007;117(1-2):57-8.
- Stewart PM. Mineralocorticoid hypertension. Lancet. 1999;353(9161):1341-7.
- Landau E, Amar L. Primary aldosteronism and pregnancy. In Annales d'endocrinologie. 2016; 77(2):148-60.
- Vaidya A, Mulatero P, Baudrand R, Adler GK. The expanding spectrum of primary aldosteronism: implications for diagnosis, pathogenesis, and treatment. Endocrine reviews. 2018;39(6):1057-88.
- Kronenberg H, Melmed S, Polonsky K, Larsen P.. Williams Textbook of Endocrinology. 11th ed. Philadelphia, PA: Saunders; 2008
- Catena C, Colussi G, Nadalini E, Chiuch A, Baroselli S, Lapenna R, Sechi LA. Cardiovascular outcomes in Ipatients with primary aldosteronism after treatment. Arch Intern Med. 2008;168(1):80-5.
- Monticone S, Burrello J, Tizzani D, Bertello C, Viola A, Buffolo F, Gabetti L, Mengozzi G, Williams TA, Rabbia F, Veglio F. Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice. J Am Coll Cardiol. 2017;69(14):1811-20.
- Hundemer GL, Curhan GC, Yozamp N, Wang M, Vaidya A. Cardiometabolic outcomes and mortality in medically treated primary aldosteronism: a retrospective cohort study. Lancet Diab Endocrinol. 2018;6(1):51-9.
- Murata M, Kitamura T, Tamada D, Mukai K, Kurebayashi S, Yamamoto T, Hashimoto K, Hayashi RD, Kouhara H, Takeiri S, Kajimoto Y. Plasma aldosterone level within the normal range is less associated with cardiovascular and cerebrovascular risk in primary aldosteronism. J Hypertens. 201;35(5):1079-85.
- Sechi LA, Novello M, Lapenna R, Baroselli S, Nadalini E, Colussi GL, Catena C. Long-term renal outcomes in patients with primary aldosteronism. JAMA. 2006;295(22):2638-45.
- Salcuni AS, Palmieri S, Carnevale V, Morelli V, Battista C, Guarnieri V, Guglielmi G, Desina G, Eller‐Vainicher C, Beck‐Peccoz P, Scillitani A. Bone involvement in aldosteronism. J Bone Min Res. 2012;27(10):2217-22.
- Morton A. Primary aldosteronism and pregnancy. Pregnancy Hypertension. Int J Women's Cardiovasc Health. 2015;5(4):259-62.
- Corsello SM, Paragliola RM. Evaluation and Management of Endocrine Hypertension During Pregnancy. Endocrinology and metabolism clinics of North America. 2019;48(4):829-42.
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