Serum Uric Acid as a Predictor of Perinatal Outcome in Women withPre-eclampsia: A prospective Cohort Study

Authors

Abstract

Objective: To assess the connection among elevated serum uric acid (SUA) levels and adverse fetal outcomes in women with pre-eclampsia.

Methods

This Prospective, cohort study was conducted in the Department of Obstetrics & Gynecology, Fauji Foundation Hospital Rawalpindi. Ethical approval was granted by the ERC of the hospital. A total of 60 women (30 exposed and 30 unexposed) of age 18-40 years were included. Patients with already taking medications for hyperuricemia, chronic hypertension, CRF and severe systemic illness like uncontrolled diabetes mellitus type 2, heart diseases were excluded. Group A (exposed) included the females with serum uric acid levels ≥6 mg/dl on presentation while Group B (unexposed) included pregnant females with serum uric acid levels <6 mg/dl . Data was analyzed using SPSS-25.0

Results

 The study results indicated that 50.0% of women with serum uric acid level of ≥6 mg/dl and pre-eclampsia experienced low birth weight, whereas only 26.67% of women having a SUA level of <600 mg/dl and preeclampsia had this outcome. Additionally, 40.0% of women with pre-eclampsia and high serum uric acid levels had intrauterine growth retardation, compared to 6.67% of those with lower serum uric acid levels. NICU admission was also more common in women with serum uric acid ≥6 mg/dl (23.33%) and pre-eclampsia as compared to those with <600 mg/dl (6.67%). These findings, with a p-value of <0.05 and a relative risk of >1, signify a significant and positive association between elevated serum uric acid levels and adverse outcomes for both the fetus and the mother.

Conclusion

 This study concluded that there is a positive association between high serum uric acid levels and adverse feto-maternal outcome.

Keywords:

Preeclampsia, Uric acid, Feto-maternal outcome

Published

2024/12/09

Issue

Vol. -Issue 4
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