Comparison of 1,3-Beta-D-Glucan & Galactomannan Antigens inEarly Diagnosis of Invasive Fungal Infections
Abstract
Objective: To compare the efficacy of 1,3-beta-D-glucan & galactomannan antigens for early diagnosis of invasive fungal infections (IFIs).Methods
This was a comparative cross-sectional study conducted at Pathology department, King Edward Medical University, Lahore for 6 months. 37 confirmed patients of IFIs were enrolled. Venous samples were taken carefully in sterile serum cups from all patients and samples were divided in 2 groups on the basis of antigen biomarker applied i.e. BDG and Galactomannan. BDG of >80 pg/ml was declared positive while galactomannan index > 0.5 was taken as positive. Data was analyzed in SPSS-26.Results
The mean age was 42.43±14.83 years. Out of 37, 26 (70.27%) were males and 11 (29.73%) females. Candida was seen in 21 (56.76%), mucor in 8 (21.62%), aspergillus in 6 (16.22%) and trichosporon in 2 (5.41%) patients. BDG showed positive for 23 (62.16%) and negative for 14 (37.84%) IFIs while Galactomannan was positive for 6 (16.22%) and negative for 31 (83.78%) IFIs. The sensitivity of BDG was 62.16% and Galactomannan was 16.22%. The comparison between two biomarkers was significant (p=0.037).Conclusion
BDG was more effective than galactomannan for early diagnosis of IFIsKeywords:
Invasive Fungal Infections, comparison, 1,3-beta-D-Glucan, Galactomannan.Published
2026/06/03
Issue
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