Platelet Indices in Diabetes Mellitus Indicating Severity of Diabetic Microvascular Complications
AbstractThe main purpose of this article was to compare the platelet volume parameter in patients with and without diabetic micro vascular complications and to evaluate the relationship and link between platelet volume indices and severity of micro vascular complications in diabetics.
MethodsThis cross sectional comparative study was carried out at Diabetic Clinic of Mayo Hospital Lahore from 23-01-2015 to 31-07-2015. Sample size of 444 well controlled (on oral hypoglycemic) diabetic patients above 30 years of age from both gender were taken with exclusion of having any haematological disorder, end stage renal disease, ischemic heart disease, stroke, any malignancy or usage of antiplatelet drugs. Venous blood samples of all patients were analyzed for full blood count. Midstream urine specimens of all patients were analyzed by spot urine protein to creatinine ratio for quantification of proteinuria. Fundoscopy of all patients were done by ophthalmologist of Ophthalmology Department of same hospital. Neurological examination of all patients for peripheral neuropathy was done.
Results Four hundred and forty four patients, 185 male (41.7 %) and 259 female (58.3%) with mean age of 52.4 ±7.9 years having good control (on oral hypoglycemic) diabetic patients were enrolled for study. In this study, 222 (50%) patients were without complications, 52 (11.7%) patients were with nonproliferative retinopathy (NPDR), 14 (3.2%) patients were with proliferative retinopathy (PDR), 54 (12.2%) patients had early nephropathy, 25 (5.6%) patients had advanced nephropathy, 30 (6.8%) patients had early neuropathy, 24 (5.4%) patients had advanced neuropathy and 23 (5.2%) patients had 2 complications. Patients with diabetic microvascular damage have high MPV values as compared to diabetics without these damage (P < 0.0001). Same results were observed for PDW values (P < 0.0001).
Conclusion Platelet volume indices (PVI) are high in diabetics with early and advanced micro vascular damage as compared to diabetics without micro vascular damage.
Keywords:Diabetes mellitus, platelet volume parameter, retinopathy, neuropathy, nephropathy.
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