Diagnostic accuracy of ultrasonography for diagnosis of congenital hypothyroidism in neonates taking scintigraphy as gold standard
AbstractObjective: To assess the diagnostic accuracy of ultrasonography for diagnosis of congenital hypothyroidism in neonates taking scintigraphy as gold standard.
MethodsThis Cross-sectional, validation study was undertaken in Department of Pediatrics, Mayo Hospital, Lahore during August2017 to February 2018. A total of 202 neonates who met the inclusion criteria were included in the study. Then neonates underwent thyroid ultrasonography. Neonates were labeled as positive or negative for congenital hypothyroidism. Then all neonates underwent scintigraphy as per hospital protocol. Reports were assessed and neonates were confirmed as positive or negative for congenital hypothyroidism. All data was entered in specially designed Performa. The data was analyzed in SPSS version 20.
Results The mean age of neonates was 13.02±7.55days. There were 97 (48%) males and 105 (52%) females. The mean weight of neonates was 2.28±0.39kg. On ultrasound, 76 (37.6%) neonates who have congenital hypothyroidism while 126 (62.4%) neonates had normal thyroid levels. On scintigraphy, 85 (42.1%) neonates who have congenital hypothyroidism while 117 (57.9%) neonates had normal thyroid levels. The sensitivity of ultrasound was 82.4%, “specificity was 94.9%, PPV was 92.1%, NPV was 88.1% and diagnostic accuracy was” 89.6% respectively taking scintigraphy as gold standard.
Conclusion Thus the ultrasound is accurate enough that it can detect congenital hypothyroidism instead of going for interventional procedure of scintigraphy, which includes radioactive material.
Keywords:Ultrasonography, congenital hypothyroidism, neonates, scintigraphy
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