A Rare Case of Gemcitabine-Induced Thrombotic Microangiopathy (TMA) in the Treatment ofMetastatic Nasopharyngeal Carcinoma, presenting to Nephrology Division Khyber TeachingHospital, Peshawar

Authors

  • Author- Muhammad Najumusaqib, Hamza Fazal, Muhammad Sana Ullah, Annum Riaz Ahmed, Zaryaab Ahmad Khan, Faizan Banaras

Abstract

: Platinum-based concomitant chemo radiotherapy is considered the standard therapy in patients with advanced nasopharyngeal carcinoma worldwide. Gemcitabine, a nucleoside analogue of cytarabine primarily authorized in 1996 for the cure of unrespectable pancreatic carcinoma. Gemcitabine causes endothelial injury directly and therefore may lead to thrombotic microangiopathy in cancer population

Keywords:

Gemcitabine(GEM), Nasopharyngeal carcinoma(NPC), Thrombotic Microangiopathy (TMA), Gemcitabineinduced thrombotic microangiopathy (GiTMA)

Published

2023/11/29

Issue

Vol. -ISSUE 4
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