Assessment of QTc Interval Prolongation and its Relationship withGlycemic Control in Diabetic Populations across Demographic andClinical Spectrums


  • Author- Shahnaz Noor, Rabia Saeed, Sara Khan, Muhammad Haroon Bilal, Naveed Nayyer, Jalil Iqba


Objective: To assess the QTc Interval Prolongation and its Relationship with Glycemic Control in Diabetic Populations across Demographic and Clinical Spectrums.


: This cross-sectional study was carried out with outpatients visiting the Department of Medicine at Quaid-e-Azam Medical College in Bahawalpur, from November 2022 to May 2023. It involved a total of 255 diabetic patients, encompassing both genders, aged between 40 and 70 years. The focus was on evaluating the prolonged QTc interval.


 : The mean age of the patients is 54.23 ± 9.49 years, the HbA1c level is 7.32 ± 0.449, and the mean QTc interval is 439.88±14.795milliseconds,respectively.Among the 255 diabetic patientsstudied, prolongedQTcwas noted in 98 (38%) of them. ThemeanHbA1c levelfor patientswith prolongedQTc is 7.40 ± 0.374 contrastingwith a slightly lowermean of 7.27 ± 0.485 inpatientswithoutprolongedQTc.The statisticalsignificanceofthis difference is underscoredbyaPvalueof0.024.


 : In conclusion, our study of 255 diabetic patients, showed a high prevalence of prolonged QTc intervals, observed in 38% of the patients. The study highlighted a significant correlation between prolonged QTc intervals and HbA1c levels, particularly pronounced in specific demographic and clinical subgroups. Elevated HbA1c levels were more frequently associated with QTc prolongation, especially in younger patients (40-55 years) and those with dyslipidemia. However, the study found no significant difference in QTc prolongation between genders.


: QTc dispersion, Glucose variability, type 2 diabetes, ECG, QTinterval