Diagnostic Accuracy of L-FABP-to-Creatinine Ratio (LCR) forPrediction of Kidney Damage in Type-2 DM Patients TakingAlbumin-to-Creatinine Ratio (ACR) as Gold Standard
Abstract
Objective: To determine the diagnostic accuracy of LCR for the prediction of kidney damage in Type-2 Diabetes Mellitus patients keepingACR as gold standard.Methods
It was a descriptive study conducted in diabetic center of Lahore General Hospital on 70 Type 2 diabetics, 35 to 55 years old having negative spot urine dipstick test for albumin.After informed consent, urine samples were collected for measurements of ACR and LCR. Patients with cardiovascular disease, hypertension, liver disease, pregnancy, anemia or any other chronic disease were excluded.ACR 30-300 mg/g was labeled as having Diabetic Nephropathy (DN). Data was analyzed in SPSS-27.Results
The mean ± SD age, BMI, duration of DM of participants was 49.6 ± 4.7 years, 29.3 ± 3.0 kg/m2, 6.2 ± 1 years respectively. Using 5.5 µg/g cut off value for LCR, the sensitivity, specificity, positive predictive value, negative predictive value, Youden's index and overall diagnostic accuracy was 85.5%, 93.3%, 0.98, 0.6, 0.78 and 0.87 respectively. Area under curve (AUC) was 0.81.Conclusion
L-FABPhas overall good diagnostic accuracy to predict kidney damage in Type-2 diabetics.Keywords:
Albumin, Creatinine, Liver type FattyAcid Binding Protein, Creatinine, Type 2 DM, Kidney damagePublished
2024/12/09
Issue
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments psimjournal@gmail.com