Study of Platelet to Lymphocyte Ratio as a Predictor Inflammatory Markerfor Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus

Authors

Abstract

Objective: To compare ratio of platelet to lymphocyte (PLR) in diabetic patients with nephropathy to those diabetics without nephropathy.

Methods

: It was an observational study carried out in the medical department from June 2022 to May 2023. A total of 246 patients of type 2 diabetes mellitus hospitalized in all medical wards were included. Based on urinary albumin excretion, two groups of patients were formed: diabetics without nephropathy (Group A) and diabetics with nephropathy (Group B). Ratio of Platelet to lymphocyte was calculated by dividing platelet count with lymphocyte count and ratio of neutrophil to lymphocyte (NLR) was calculated by dividing neutrophil to lymphocyte count. PLR and NLR were compared amongst both groups.

Results

  There were 246 subjects (111 females, 134 males). 131 subjects did not have nephropathy, 115 patients had nephropathy. Comparison of hematological parameters showed that NLR of patients with type 2 DM with nephropathy was 2.59 ± 0.51 and without nephropathy group was 1.70 ± 0.44. The PLR of diabetic nephropathy group was 251 ± 62.4 and that without nephropathy was 213 ± 59.6. Statistical significance (p < 0.05) was seen in the NLR and PLR values of the two groups when compared using the student t-test.

Conclusion

  Increased ratio of platelet-to-lymphocyte significantly correlates with diabetic nephropathy, and may serve as a predictor inflammatory marker for diabetic nephropathy.

Keywords:

Diabetic Nephropathy, platelet-to-lymphocyte ratio, type 2 Diabetes mellitus

Published

2025/03/10

Issue

Vol. -ISSUE 1
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