Comparing Vaginal Misoprostol with Intraoperative OxytocinInfusion in Blood Loss during Abdominal Myomectomy
Abstract
Objective: To compare a single dose of vaginal misoprostol versus oxytocin infusion in terms of mean blood loss during abdominal myomectomy.Methods
This Randomized controlled trial was conducted on 100 females from OPD department of Gynecology, District Headquarter Hospital Gujranwala during November 2019 to April 2020. Females were split randomly in two equal groups. In group A, two tablets of misoprostol i.e. 400 micrograms were given via vaginal route 20 minutes before induction of anesthesia. Twenty minutes before induction of anesthesia and during myoma excision, females in group B received 30 units of oxytocin in 1000 ml normal saline at a rate of 120 ml /min. Blood loss was measured. Data was analyzed using IBM. SPSS Version 20. Independent sample t-test was used to compare the two groups for blood loss during surgery. Statistical significance was assumed at a p value of less than <0.05.Results
The mean age of the patients was 35.69 ± 8.162 years. The age stratification has been shown below. The mean BMI was 24.70 ± 3.040 kg/m2. The largest dimension of the fibroid was 7.57 ± 3.036 cm. The quantitative variables were compared among groups. There was no difference between groups in terms of age, BMI and dimension of the fibroid (p values 0.519, 0.149, 0.922 respectively). However, there was a difference among the groups regarding blood loss during surgery. The blood loss in group A was 452.04 ± 27.461 ml and in group B was 475.62 ± 51.752 ml (p values 0.005). The data was stratified according to age, BMI, type and location of the fibroid. The results showed there was blood loss difference among groups in the following groups only; Age <35 years, > 35 years, BMI <25 kg/m2, intramural location and fibroids dimension <7cm (p value 0.005, 0.021, 0.001, <0.0001, <0.0001).Conclusion
During abdominal myomectomy, a single dose of vaginal misoprostol is more effective than oxytocin infusion for reducing blood loss.Keywords:
Intraoperative blood loss, Myomectomy, Oxytocin, Uterine fibroidsPublished
2025/03/10
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