Short-Term Outcomes in Membranous Nephropathy: Insights from A Single Study Center
Abstract
Objective: To determine the short-term outcomes of membranous nephropathy (MN) in patients visiting outpatient department of nephrology, Bahawal Victoria Hospital, Bahawalpur.Methods
Patients of either gender and any age, having renal biopsy proven MN, visiting outpatient department of nephrology between October 2021 to August 2024, and treated for a minimum duration of 6 months were analyzed. All of the patients underwent a systematic physical examination, and detailed information about their medical history was gathered. Patients were then subjected to necessary baseline investigations. Follow up visits were planned every month and final outcome was labeled after 6 months treatment.Results
In a total of 178 patients with MN, the mean age was 32.25±12.86 years. There were 117 (65.7%) male patients. The mean duration of symptoms was 7.80±13.04 months. Most frequent types of treatment advised were conservative and cyclical regimens used in 80 (44.9%), and 33 (18.5%) patients, respectively. Post-treatment, 74 (41.6%) patients had complete proteinuria remission, 93 (52.2%) partial remission, whereas 11 (6.2%) patients had nephrotic proteinuria progression. Post-treatment proteinuria status was having significant association with duration of symptoms (p=0.003), baseline proteinuria (p<0.001), baseline serum albumin (p=0.024), baseline progression risk score (p=0.001), and treatment types (p=0.001). Post-treatment, 134 (75.3%) patients did not report renal dysfunction.Conclusion
This study emphasizes the importance of baseline parameters and treatment modalities in predicting and influencing post-treatment outcomes in MN, providing valuable insights for more targeted and effective patient care. Favorable short-term outcomes were reported in vast majority of patients with membranous nephropathy.Keywords:
Membranous nephropathy, Nephrotic proteinuria, Proteinuria, Serum albumin, Serum creatinine.Published
2025/06/05
Issue
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