Case Report

A Rare Case of Gemcitabine-Induced Thrombotic Microangiopathy (TMA) in the Treatment of Metastatic Nasopharyngeal Carcinoma, presenting to Nephrology Division Khyber Teaching Hospital, Peshawar

Muhammad Najumusaqib
Khyber Teaching Hospital Peshawar
Hamza Fazal
Khyber Teaching Hospital Peshawar
Muhammad Sana Ullah
Khyber Teaching Hospital Peshawar
Annum Riaz Ahmed
Khyber Teaching Hospital Peshawar
Zaryaab Ahmad Khan
Khyber Teaching Hospital Peshawar
Faizan Banaras
Khyber Teaching Hospital Peshawar

✉ Correspondence: Muhammad Najumusaqib Email: muhammadnajumusaqib24881@import.invalid

DOI https://doi.org/10.70302/jpsim.v4i4.2367
Volume: 4, Issue 4 Pages: 330–332 Published: 29 Nov 2023
Received: 19 Jul 2023 Accepted: 14 Sep 2023 Published Online: 29 Nov 2023

Abstract

Platinum-based concomitant chemo radiotherapy is considered the standard therapy in patients with advanced nasopharyngeal carcinoma worldwide. Gemcitabine, a nucleoside analogue of cytarabine primarily authorized in 1996 for the cure of unrespectable pancreatic carcinoma. Gemcitabine causes endothelial injury directly and therefore may lead to thrombotic microangiopathy in cancer population.

Keywords
Gemcitabine(GEM) Nasopharyngeal carcinoma(NPC) Thrombotic Microangiopathy (TMA) Gemcitabineinduced thrombotic microangiopathy (GiTMA)

How to Cite This Article

Najumusaqib M, Fazal H, Ullah MS, Ahmed AR, Khan ZA, Banaras F. A Rare Case of Gemcitabine-Induced Thrombotic Microangiopathy (TMA) in the Treatment of Metastatic Nasopharyngeal Carcinoma, presenting to Nephrology Division Khyber Teaching Hospital, Peshawar. J Pak Soc Intern Med. 2023;4(4):330–332. doi:10.70302/jpsim.v4i4.2367

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2023 Journal of Pakistan Society of Internal Medicine.
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