Original Research

Posaconazole as a Treatment for Rhinosinusitis Mucormycosis

Kamran Amir Khan1
North West General Hospital, Peshawar
Sameed Ullah Qureshi1
North West General Hospital, Peshawar
Zuhra Naheed Khan
Maryam Saleem Raza2
Pakistan Kidney & Liver Institute, Lahore
Imran Mohib Khan1
North West General Hospital, Peshawar

✉ Correspondence: Kamran Amir Khan Email: kkhan@nwgh.pk

DOI https://doi.org/10.70302/jpsim.v6i1.2510
Volume: 6, Issue 1 Pages: 47–51 Published: 10 Mar 2025
Received: 28 Apr 2024 Revised: 10 Feb 2025 Accepted: 22 Feb 2025 Published Online: 10 Mar 2025

Abstract

Objective

To determine the performance of Posaconazole as a salvage therapy in patients with rhino-orbital-cerebral mucormycosis.

Methods

After the ethical committee gave its approval, this cross-sectional study was performed at the Northwest General Hospital & Research Centre, Peshawar, Pakistan. It comprised of data of patients diagnosed with mucormycosis from January 2018 to June 2021. All the patients underwent surgical intervention and were given Posaconazole either as salvage therapy or along with Amphotericin B for the treatment of mucormycosis. Convenient sampling was used and a structured format was used for data collection. SPSS 21 was used for data analysis.

Results

Out of the 16 patients, 14 patients improved with Posaconazole with a reduction in the lesions. All 16 patients underwent surgical procedure for debridement and given both Amphotericin and Posaconazole. One patient died due to sepsis, and another patient died due to complications of COVID-19 infection. The remaining 14 patients recovered from the surgery, one patient was lost to follow up, and one patient suffered a re-infection, but recovered with Posaconazole.

Conclusion

The study highlights the benefit of using Posaconazole either as combined therapy, single use or as a step down therapy for mucormycosis with minimal side effects.

Keywords
Posaconazole mucormycosis fungal infection rhinosinusitis

How to Cite This Article

Khan KA, Qureshi SU, Khan ZN, Raza MS, Khan IM. Posaconazole as a Treatment for Rhinosinusitis Mucormycosis. J Pak Soc Intern Med. 2025;6(1):47–51. doi:10.70302/jpsim.v6i1.2510

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2025 Journal of Pakistan Society of Internal Medicine.
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