Case Report

Adult Type BCR-ABL Positive CML: A Case Report of Southern Punjab

DOI https://doi.org/10.70302/jpsim.v6i1.2518
Received: 15 Feb 2024 Revised: 19 Feb 2025 Accepted: 23 Feb 2025 Published Online: 10 Mar 2025

Abstract

Chronic Myeloid Leukemia is the commonest type of myeloproliferative neoplasm. Peak age group of this illness is 27 to 66 years. The purpose of this case report is to emphasize the occurrence of rare cases and to help clinicians in diagnosing diseases with uncommon presentation. Current case report study was performed in Sheikh Zayed Medical College / Hospital Rahim Yar Khan, Pakistan from february 2022 to March 2022. A 17 years old male patient was included in this study. Complete Blood Count with peripheral smear, bone marrow aspiration and trephine biopsy were performed in Hematology department Sheikh Zayed Hospital Rahim Yar Khan, while fluorescence in situ hybridization analysis for Bcr-Abl fusion gene was performed at Agha Khan University Hospital Laboratory Karachi. Translocation was detected (98%) amongst 200 nuclei scored. Based on this study, possibility of chronic myeloid leukemia in young patients must not be ignored.

Keywords
Chronic myeloid leukemia Flourescence in situ hybridization Bcr-Abl.

How to Cite This Article

Irfan QM, Khan S, Sarwar F, Ahmed I. Adult Type BCR-ABL Positive CML: A Case Report of Southern Punjab. J Pak Soc Intern Med. 2025;6(1):86–87. doi:10.70302/jpsim.v6i1.2518

⭳ Download PDF

Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

  1. Coltro G, Loscocco GG, Vannucchi AM. Classical Philadelphia-negative myeloproliferative neoplasms (MPNs): A continuum of different disease entities. International Rev Cell Mol Biol. 2021;365(1):1-69.
  2. Shallis RM, Wang R, Davidoff A, Ma X, Podoltsev NA, Zeidan AM. Epidemiology of the classical myeloproliferative neoplasms: the four corners of an expansive and complex map. Blood Rev. 2020;42(1):100706.
  3. Kim JC. Origin of disease heterogeneity in BCR-ABL1 lymphoblastic leukemia [Doctoral dissertation, University of Toronto (Canada)].
  4. Tavares RS, Nonino A, Pagnano KB, Nascimento AC, Conchon M, Fogliatto LM, Funke VA, Bendit I, Clementino NC, Chauffaille MD, Bernardo WM. Guideline on myeloproliferative neoplasms: Associação Brasileira de Hematologia, Hemoterapia e Terapia Cellular Project guidelines: Associação Médica Brasileira–2019. Hematol Trans Cell Therap. 2019;41(Suppl 1):1-73.
  5. Jabbour E, Kantarjian H. Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management. Am J Hematol. 2014;89(5):547-56.
  6. Risques RA, Kennedy SR. Aging and the rise of somatic cancer-associated mutations in normal tissues. PLoS Genet. 2018;14(1):e1007108.

Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2025 Journal of Pakistan Society of Internal Medicine.