Case Report

Kounis Syndrome Following Ceftriaxone Administration

DOI https://doi.org/10.70302/jpsim.v7i2.2633
Received: 11 Nov 2025 Revised: 14 Apr 2026 Accepted: 04 May 2026 Published Online: 03 Jun 2026

Abstract

Kounis syndrome, also known as allergic acute coronary syndrome, represents the concurrence of acute coronary events with hypersensitivity reactions. It is an under recognized but potentially fatal condition triggered by drugs, foods, insect stings, or environmental exposures1. We report a case of suspected Kounis syndrome following intravenous ceftriaxone administration, presenting with anaphylactic shock, respiratory failure requiring mechanical ventilation, and biochemical evidence of myocardial injury. The patient recovered with supportive and anti allergic management without undergoing coronary angiography. This case highlights the importance of early recognition of Kounis syndrome in patients who develop cardiovascular collapse after exposure to potential allergens

Keywords
Kounis syndrome allergic myocardial infarction ceftriaxone anaphylaxis troponin elevation Sunjay Kapur Karisma Kapoor

How to Cite This Article

Saeed MK, Siddique F, Mishaal M. Kounis Syndrome Following Ceftriaxone Administration. J Pak Soc Intern Med. 2026;7(2):163–164. doi:10.70302/jpsim.v7i2.2633

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

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