Knowledge, Perceptions and Misconceptions Regarding HPV Vaccination among Adolescent Girls in Pakistan
Abstract
To assess the knowledge, perceptions and misconceptions regarding Human Papillomavirus (HPV) infection and HPV vaccination among adolescent girls in Pakistan.
This was a cross-sectional survey-based study conducted over a defined study period in schools and community settings. Adolescents falling within the recommended age range for HPV vaccination were included. Data regarding demographic profile, awareness of HPV, knowledge of its association with cervical cancer, understanding of HPV vaccination, and perceived barriers to vaccination was collected and analyzed.
A total of 633 respondents participated in the survey. The most common age was 13 years and overall awareness regarding HPV was 57%. Among the participants, 628 (99%) were females and 5 (1%) were males. Four hundred and ten (65%) participants had secondary education, 118 (19%) had no formal education, 64 (10%) had primary education and 41 (6%) had higher education. Overall, 432 (68%) participants linked HPV with cervical cancer, 505 (80%) knew that HPV vaccination is recommended for prevention of cervical cancer, and 439 (69%) knew that the vaccine prevents cervical cancer. The most common barriers to vaccination were myths and misconceptions 195 (31%), cultural concerns 192 (30%), lack of awareness 149 (24%), access issues 90 (14%) and cost 74 (12%).
Awareness regarding HPV and HPV vaccination among adolescent girls in Pakistan was moderate, with myths, misconceptions and cultural concerns being the major barriers to vaccination. Since the participants belonged to the adolescent age group, early educational intervention is crucial. Targeted school-based awareness programs may help reduce misconceptions, improve knowledge, and increase HPV vaccination acceptance in Pakistan.
How to Cite This Article
Khanum F, Alvi AO, Waheed M, Shahid A, Noor M, Khan MA. Knowledge, Perceptions and Misconceptions Regarding HPV Vaccination among Adolescent Girls in Pakistan. J Pak Soc Intern Med. 2026;7(3):238–243. doi:10.70302/jpsim.v7i3.2645
Conflict of Interest
The authors declare no conflict of interest.
Funding
This research received no specific grant from any funding agency.
Funder information follows the Crossref Funder Registry standard.
References
- World Health Organization. Human papillomavirus (HPV) and cancer .Geneva: World Health Organization; 2024 Mar 5 [cited 2026 May 6]. Available from: [https://www.who.int/news-room/fact-sheets/detail/human-papilloma-virus-and-cancer]
- Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, et al. Global burden of human papillomavirus and related diseases. Vaccine. 2012;30(Suppl 5):F12–F23.
- Centers for Disease Control and Prevention. Human papillomavirus (HPV): transmission. Atlanta: Centers for Disease Control and Prevention; 2024. Available from: [https://www.cdc.gov/hpv/parents/about-hpv.html]
- History of HPV vaccines and screening. STO Online; [cited 2026 May 6]. Available from: [https://so to-online.org/harmony/history-of-hpv-vaccines-and-screening/]
- Action C.C. Global progress in HPV vaccination. 2015 [cited 2016 Jun 14]. Available from: [http://www.cervicalcanceraction.org/comments/comments3.php]
- World Health Organization. Comprehensive cervical cancer prevention and control: a healthier future for girls and women [Internet]. Geneva: World Health Organization; 2013 [cited 2026 May 6]. Available from: [https://www.who.int/publications/i/item/9789241505147]
- ICO/IARC Information Centre on HPV and Cancer. Human papillomavirus and related diseases in Pakistan: summary report 2015. Barcelona: ICO/IARC Information Centre on HPV and Cancer; 2015. Available from: [https://hpvcentre.net/statistics/reports/PAK.pdf]
- Khan S, Jaffer NN, Khan MN, Rai MA, Shafiq M, Saba N, et al. Human papillomavirus subtype 16 is common in Pakistani women with cervical carcinoma. Int J Infect Dis. 2007;11(4):313–7.
- Shamsi U, Zahid F, Jabbar ABA, Musharraf MD, Gauhar F, Akbar I, et al. Human papillomavirus vaccine awareness and acceptability for primary prevention of cervical cancer in Pakistan: a cross-sectional study. Asian Pac J Cancer Prev. 2024;25(3):813–20.
- Alghalyini B, Zaidi ARZ, Meo SA, Faroog Z, Rashid M, Alyousef SS, et al. Awareness and knowledge of human papillomavirus, vaccine acceptability and cervical cancer among college students in Saudi Arabia. Hum Vaccin Immunother. 2024;20(1):2403844.
- Dewan M, Shukla D, Shrivastav G, Diwan P. Knowledge and attitude towards HPV infection, HPV vaccination and cervical cancer among middle- and high-school students in Gwalior. J Family Med Prim Care. 2024;13(10):4382–7.
- Singh A, Dandekar SP, Dhumale GB, Khairnar MR. Effect of health education on the knowledge and attitude regarding the human papillomavirus vaccine among adolescent school girls of a city in western Maharashtra. Indian J Community Health. 2024;36(3):2822.
- Abdelhadi LM, Aryan FS, Alsabi R, Samhan GA, Al-Qaaneh AM. Knowledge, attitudes, and practices associated with human papillomavirus vaccine recommendation among healthcare professionals: a cross-sectional study. Infect Dis Rep. 2025;17(5):126.
- Emon HH, Kowbi RN, Chowdhury MN, Teep TR, Habib MA, Tayeeba F, et al. Assessing knowledge, attitudes, and barriers toward HPV cervical cancer and vaccination among female university students in Bangladesh. Sci Rep. 2025;15(1):44529.
- Rakheja S, Mehta D, Aggarwal I, Goel H, Joseph D, Jain J, et al. Knowledge, attitude and awareness of HPV vaccination among college-going girls (18–26 years) in Delhi NCR. Asian Pac J Cancer Nurs. 2025; doi:10.31557/apjcn.1967.20250806. doi:10.31557/apjcn.1967.20250806
- Hristamyan M, Rangelova V, Lolovski T, Homadi M, Kevorkyan A. Study of the knowledge, attitudes and practices of students from medical majors regarding HPV infections and HPV vaccines. Pathogens. 2025; 14(12):1270.
- Atif N, Hashmi FK, Malik UR, Ghauri MA, Gillani AH, Kadirhaz M, et al. From awareness to acceptance: understanding HPV and vaccine knowledge, attitudes and beliefs among university students in Punjab, Pakistan. J Pharm Policy Pract. 2025;18(1):2473023.
- Zheng S, Deng X, Li L, Luo F, He H, Wang Y, Xu X, Wang S, Chen Y. Awareness, preference, and acceptance of HPV vaccine and related influencing factors among guardians of adolescent girls in China: a health belief model-based cross-sectional study. Vaccines (Basel). 2025;13(8):840.
- Li W, Jin Y, Li X, et al. Human papillomavirus and vaccine knowledge, willingness, and uptake among university students: a systematic review and meta-analysis. BMC Public Health. 2025;25(1):4268.
- Akhter N, Nasrin S. Knowledge, practice and awareness of adolescent girls on human papillomavirus vaccine. Int J Reprod Contracept Obstet Gynecol. 2025;14(2):426–30.
Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.