Original Research

Lactate Dehydrogenase as a Predictor of Disease Severity in Coronavirus Disease (Covid-19)

Tayyeba Komal1
King Edward Medical University, Mayo hospital, Lahore
Sami Ullah Mumtaz1
King Edward Medical University, Mayo hospital, Lahore
Sana Rafique1
King Edward Medical University, Mayo hospital, Lahore
Akhtar Ali2
Shalamar Medical and Dental College, Shalamar Hospital, Lahore
Somia Iqtadar1
King Edward Medical University, Mayo hospital, Lahore
Israr Ul Haque1
King Edward Medical University, Mayo hospital, Lahore

✉ Correspondence: Tayyeba Komal Email: drtksami@gmail.com

DOI https://doi.org/10.70302/jpsim.v5i1.2410
Volume: 5, Issue 1 (Women Issue) Pages: 404–406 Published: 28 Feb 2024
Received: 12 Oct 2023 Accepted: 16 Dec 2023 Published Online: 28 Feb 2024

Abstract

Objective

To find out association between serum lactate dehydrogenase levels and coronavirus disease severity.

Methods

It was a cross sectional study done at mayo hospital Lahore for six months.100 patients of age 15-80 years of either gender having COVID-19 PCR positive were included. Serum LDH levels were sent at the time of admission, day 7 & day 14 to the pathology laboratory KEMU.To assess clinical severity of coronavirus disease, all the enrolled patients were categorized as mild, moderate, severe & critical cases on the basis of oxygen/mechanical ventilation requirement .Data was analyzed using SPSS-26.

Results

A very strong positive correlation observed between serum LDH level a severity of corona virus disease i.e. r = 0.906, p-value < 0.00001. LDH showed Sensitivity 59.52%, Positive Predictive Value 30.12% and Diagnostic Accuracy 25%.

Conclusion

LDH is a strong predictor of COVID-19 disease severity. Thereforein future LDH can be used to see disease severity.

Keywords
: Lactate Dehydrogenase Predictor Severity COVID-19

How to Cite This Article

Komal T, Mumtaz SU, Rafique S, Ali A, Iqtadar S, Haque IU. Lactate Dehydrogenase as a Predictor of Disease Severity in Coronavirus Disease (Covid-19). J Pak Soc Intern Med. 2024;5(1):404–406. doi:10.70302/jpsim.v5i1.2410

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

References

  1. Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, et al. epidemiological, clinical, virological characteristics of 74 cases of coronavirus infection disease 2019(COVID-19) with gastrointestinal symptoms. Gut. 2020; 69(6): 1002-9.
  2. World Health Organization Coronavirus disease 2019 (COVID-19) pandemic. 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019.
  3. Gao QY, Chen YX, Fang JY. 2019 novel coronavirus infection and gastrointestinal symptoms. JDigest Dis. 2020; 21(3): 125-126.
  4. Egi M, Kim I, Nichol A, Stachowski E, French CJ, Hart GK.Ionized calcium concentration and outcome in critical illness. Crit Care Med 2011;39(2):314-21.
  5. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, Wu Y, Zhang L, Yu Z, Fang M, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475–81.
  6. Chen C.Y., Lee C.H., Liu C.Y., Wang J.H., Wang L.M., Perng R.P. Clinical features and outcomes of severe acute respiratory syndrome and predictive factors for acute respiratory distress syndrome. J Chin Med Assoc. 2005;68(1):4–10.
  7. Chiang C.H., Shih J.F., Su W.J., Perng R.P. Eight-month prospective study of 14 patients with hospital-acquired severe acute respiratory syndrome. Mayo Clin Proc. 2004;79(11):1372-9.
  8. Tao R.J., Luo X.L., Xu W. Viral infection in community acquired pneumonia patients with fever: a prospective observational study. J Thorac Dis. 2018;10(7):4387–95.
  9. Henry B.M., Aggarwal G., Wong J., et al. Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: a pooled analysis. Am J Emerg Med. 2020;38(9):1722-6.
  10. Fialek B, Pruc M, Smereka J, Jas R, Rahnama-Hezavah M, Denegri A, Szarpak A, Jaguszewski MJ, Peacock FW, Szarpak L. Diagnostic value of lactate dehydrogenase in COVID-19: A systematic review and meta-analysis. Cardiol J. 2022;29(5):751-8.
  11. Jelassi W, Mejri I, Guediri N, Daboussi S, Mhamdi S, Aichaouia Cet al. Les symptômes du bas appareilurinaire et pneumopathie COVID-19: quels liens?. Revue des Maladies RespiratoiresActualités. 2022 Jan 1;14(1):122.
  12. Martha JW, Wibowo A, Pranata R. Prognostic value of elevated lactate dehydrogenase in patients with COVID-19: a systematic review and meta-analysis.Postgrad Med J. 2022;98(1160):422-427.
  13. Huang Y, Guo L, Chen J, Wu M, Zhang C, Liu Z et al. Serum Lactate Dehydrogenase Level as a Prognostic Factor for COVID-19: A Retrospective Study Based on a Large Sample Size. Front Med. 2022;8(1):671667.
  14. Hasanah U, Kartini A, Kadir NA, Abdullah AA. Lactate Dehydrogenase Levels as A Marker of COVID-19 Severity. Indonesian JClinPathol Med Lab. 2023;29(1):81-5.
  15. Wu MY, Yao L, Wang Y, Zhu XY, Wang XF, Tang PJet al. Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia. Respir Res.2020; 21(1):171.

Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2024 Journal of Pakistan Society of Internal Medicine.
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