Original Research

Serum Uric Acid as a Predictor of Perinatal Outcome in Women with Pre-eclampsia: A prospective Cohort Study

Anum Mujeeb
Fauji Foundation Hospital, Rawalpindi-Pakistan
Hina Tabassum
Fauji Foundation Hospital, Rawalpindi-Pakistan
Atikka Masoud
Fauji Foundation Hospital, Rawalpindi-Pakistan
Madiha Ahmed
Fauji Foundation Hospital, Rawalpindi-Pakistan
Nadia Ahmed Bokhari
Fauji Foundation Hospital, Rawalpindi-Pakistan
Ambreen Fatima
Fauji Foundation Hospital, Rawalpindi-Pakistan

✉ Correspondence: Madiha Ahmed Email: vazim4847@gmail.com

DOI https://doi.org/10.70302/jpsim.v5i4.2473
Volume: 5, Issue 4 Pages: 723–728 Published: 09 Dec 2024
Received: 16 Feb 2024 Accepted: 02 Nov 2024 Published Online: 09 Dec 2024

Abstract

Objectives

To assess the connotation among elevated serum uric acid (SUA) levels and adverse fetal outcomes in women with pre-eclampsia.

Methods

This Prospective, cohort study was conducted in the Department of Obstetrics & Gynecology, Fauji Foundation Hospital, Rawalpindi. Ethical approval was granted by the ERC of the hospital. A total of 60 women (30 exposed and 30 unexposed) with of age 18-40 years were included. Patients with already taking medications for hyperuricemia, chronic hypertension, CRF and severe systemic illness like 2 uncontrolled diabetes mellitus, heart diseases were excluded. Group A (exposed) included the females with serum uric acid levels ≥6 mg/dl on presentation while Group B (unexposed) included pregnant females with serum uric acid levels. Data was analyzed using SPSS-25.0

Results

The study results indicated that 50.0% of women with serum uric acid level of ≥6 mg/dl and pre-eclampsia experienced low birth weight, whereas only 26.67% of women having a SUA level of <600 mg/dl and preeclampsia had this outcome. Additionally, 40.0% of women with pre-eclampsia and high serum uric acid levels had intrauterine growth retardation, compared to 6.67% of those with lower serum uric acid levels. NICU admission was also more common in women with serum uric acid ≥6 mg/dl (23.33%) and pre-eclampsia as compared to those with <600 mg/dl (6.67%). These findings, with a p-value of <0.05 and a relative risk of >1, signify a significant and positive association between elevated serum uric acid levels and adverse outcomes for both the fetus and the mother.

Conclusion

This study concluded that there is a positive association between high serum uric acid levels and adverse feto-maternal outcome.

Keywords
Preeclampsia Uric acid Feto-maternal outcome

How to Cite This Article

Mujeeb A, Tabassum H, Masoud A, Ahmed M, Bokhari NA, Fatima A. Serum Uric Acid as a Predictor of Perinatal Outcome in Women with Pre-eclampsia: A prospective Cohort Study. J Pak Soc Intern Med. 2024;5(4):723–728. doi:10.70302/jpsim.v5i4.2473

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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Reference list indexed for Google Scholar and ResearchGate. DOI links resolve via doi.org.

CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2024 Journal of Pakistan Society of Internal Medicine.
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