Original Research

Diagnostic Accuracy of L-FABP-to-Creatinine Ratio (LCR) for Prediction of Kidney Damage in Type-2 DM Patients Taking Albumin-to-Creatinine Ratio (ACR) as Gold Standard

Eesha Sultan1
Garrison Medical Center, Jarrar Camp Rawalpindi
Aqib Sultan2
Shaukat Khanum Memorial Cancer Hospital Lahore,
Rehma Dar3
Services Institute of Medical Sciences Lahore
Ushna Sultan4
LRBT Hospital Township Lahore
Muhammad Haris Ghani5
Punjab Institute of Cardiology Lahore
Naheeda Kousar6
PGMI Lahore

✉ Correspondence: Naheeda Kousar Email: drnaheedapgmi@gmail.com

DOI https://doi.org/10.70302/jpsim.v5i4.2465
Volume: 5, Issue 4 Pages: 690–693 Published: 09 Dec 2024
Received: 02 Jul 2024 Accepted: 14 Nov 2024 Published Online: 09 Dec 2024

Abstract

Objective

To determine the diagnostic accuracy of LCR for the prediction of kidney damage in Type-2 Diabetes Mellitus
patients keeping ACR as gold standard.

Methods

It was a descriptive study conducted in diabetic center of Lahore General Hospital on 70 Type 2 diabetics, 35 to
55 years old having negative spot urine dipstick test for albumin. After informed consent, urine samples were collected for
measurements of ACR and LCR. Patients with cardiovascular disease, hypertension, liver disease, pregnancy, anemia or
any other chronic disease were excluded. ACR 30-300 mg/g was labeled as having Diabetic Nephropathy (DN). Data was
analyzed in SPSS-27.

Results

The mean ± SD age, BMI, duration of DM of participants was 49.6 ± 4.7 years, 29.3 ± 3.0 kg/m2, 6.2 ± 1 years
respectively. Using 5.5 µg/g cut off value for LCR, the sensitivity, specificity, positive predictive value, negative
predictive value, Youden's index and overall diagnostic accuracy was 85.5%, 93.3%, 0.98, 0.6, 0.78 and 0.87 respectively.
Area under curve (AUC) was 0.81.

Conclusion

L-FABP has overall good diagnostic accuracy to predict kidney damage in Type-2 diabetics.

Keywords
Albumin Creatinine Liver type FattyAcid Binding Protein Creatinine Type 2 DM Kidney damage

How to Cite This Article

Sultan E, Sultan A, Dar R, Sultan U, Ghani MH, Kousar N. Diagnostic Accuracy of L-FABP-to-Creatinine Ratio (LCR) for Prediction of Kidney Damage in Type-2 DM Patients Taking Albumin-to-Creatinine Ratio (ACR) as Gold Standard. J Pak Soc Intern Med. 2024;5(4):690–693. doi:10.70302/jpsim.v5i4.2465

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2024 Journal of Pakistan Society of Internal Medicine.
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