Original Research

Effectiveness of Noradrenaline and Albumin vs. Terlipressin andAlbumin in Treating Hepatorenal Syndrome in Patients of ChronicLiver Disease

Hunza Malik
Services Institute of Medical Sciences / Services Hospital Lahore, Pakistan
Muhammad Arif Nadeem
Services Institute of Medical Sciences / Services Hospital Lahore, Pakistan
Abdul Waheed
Services Institute of Medical Sciences / Services Hospital Lahore, Pakistan
Tabish Raza
Services Institute of Medical Sciences / Services Hospital Lahore, Pakistan

✉ Correspondence: Muhammad Arif Nadeem Email: arifnadeem1234@gmail.com

DOI https://doi.org/10.70302/jpsim.v6i1.2506
Volume: 6, Issue 1 Pages: 26–31 Published: 10 Mar 2025
Received: 10 May 2024 Revised: 26 Jan 2025 Accepted: 22 Feb 2025 Published Online: 10 Mar 2025

Abstract

Objective

To compare the efficacy of noradrenaline and albumin versus terlipressin and albumin in the treatment of hepato-renal syndrome in patients with chronic liver disease.

Methods

This was a randomized controlled trial conducted from 2nd August 2022 to 1st February 2023 at the Department of Medicine & Gastroenterology, Medical unit III, Services Hospital Lahore. A total of 70 patients of age 18 to 70 years, both genders, diagnosed with chronic liver disease (CLD) having HRS were included. Patients with chronic kidney disease (CKD), history of ischemic heart disease, arrhythmias or cardiomyopathy were excluded. Group A received Inj. Terlipressin 1mg x 6 hourly along with Inj. Albumin 1 mg/kg on day 1 and then 20 mg/day. Group B received Nordrenaline initially 1 mg/hour along with Inj. Albumin 1 mg/kg on day 1 and then 20mg/day. Patients were followed for 48 hours. If there was decline of serum creatinine < 1.5 mg/dl within 48 hours, then efficacy was labeled.

Results

In our study, efficacy of noradrenaline and albumin was 80.0% versus 37.14% in terlipressin and albumin in treatment of hepato-renal syndrome in patients of CLD.

Conclusion

This study concluded that efficacy of noradrenaline and albumin is better than terlipressin and albumin in treatment of hepato-renal syndrome in patients of chronic liver disease.

Keywords
Liver cirrhosis hepatorenal syndrome nor-adrenaline.

How to Cite This Article

Malik H, Nadeem MA, Waheed A, Raza T. Effectiveness of Noradrenaline and Albumin vs. Terlipressin andAlbumin in Treating Hepatorenal Syndrome in Patients of ChronicLiver Disease. J Pak Soc Intern Med. 2025;6(1):26–31. doi:10.70302/jpsim.v6i1.2506

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Conflict of Interest

All authors declare no competing interests.

Disclosed in accordance with ICMJE and COPE guidelines.

Funding

No specific funding was received for this research.

Funder information follows the Crossref Funder Registry standard.

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CC BY CC BY 4.0 This article is published under the Creative Commons Attribution 4.0 International License. May be shared and adapted with attribution. © 2025 Journal of Pakistan Society of Internal Medicine.
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